Volume 112, Issue 2 p. 333-337
CONCISE REPORT-ARTICLE - COVID-19 AND RELATED TOPICS

Circulating B10 regulatory cells are decreased in severe and critical COVID-19

Rodrigo Cervantes-Díaz

Rodrigo Cervantes-Díaz

Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, México

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Víctor A. Sosa-Hernández

Víctor A. Sosa-Hernández

Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, México

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Sandra Romero-Ramírez

Sandra Romero-Ramírez

Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, México

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Jiram Torres-Ruiz

Jiram Torres-Ruiz

Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

Departamento de Atención Institucional Continua y Urgencias, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

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Alfredo Pérez-Fragoso

Alfredo Pérez-Fragoso

Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

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David E. Meza-Sánchez

David E. Meza-Sánchez

Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

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Diana Gómez-Martín

Diana Gómez-Martín

Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

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José L. Maravillas-Montero

Corresponding Author

José L. Maravillas-Montero

Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México

Correspondence

José Luis Maravillas-Montero, PhD. Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Colonia Sección XVI, Tlalpan, C.P. 14000, Mexico City, Mexico.

Email: [email protected]

Rodrigo Cervantes-Díaz, Víctor A. Sosa-Hernández, and Sandra Romero-Ramírez: Joint first authors.

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First published: 24 February 2022

Abstract

The contribution of B cells in COVID-19 pathogenesis, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Since one of their most relevant functional roles includes their immune-suppressive mechanisms, we decided to evaluate one of the most recognized human B regulatory subpopulations: the IL-10+ B10 cells, during COVID-19 onset. After stimulation of PBMCs for IL-10 induction, we employed multiparametric flow cytometry to determine B10 frequencies in severe and critical COVID-19 patients and then correlated those with clinical and laboratory parameters. Compared with healthy individuals, we detected a significant reduction in the B10 subset in both patient groups, which correlates with some inflammatory parameters that define the disease severity. This evidence suggests an aberrant role of B10 cells in immune responses against SARS-CoV-2 that needs to be further explained.

DISCLOSURES

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The data that support the findings of this study are available from the corresponding author, upon reasonable request.