ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 1125-1129
  • First Published: 23 May 2022

EDITORIAL

Free Access

Neutropenia and infections: Neutrophil replacement through genetic engineering

  • Pages: 1131-1132
  • First Published: 31 March 2022
Neutropenia and infections: Neutrophil replacement through genetic engineering
Graphical Abstract

Discussion of the 60-year history of development of granulocyte replacement therapies provides background for the report of Sykes et al in this issue of the Journal.

SPOTLIGHT ON LEADING EDGE RESEARCH

Free Access

ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19

  • Pages: 1147-1158
  • First Published: 26 November 2021
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19
Graphical Abstract

Inhibition of ADAM17 with apratastat or TMI-1 ameliorates neutrophilia and cytokine storm in a mouse model of Covid-19-related lung injury induced by poly(I:C) and the receptor-binding domain of the SARS-CoV2 Spike protein (RBD-S).

Targeted Science Issue — Neutrophil 2021

Guest Editors: Edwin Chilvers, Alison Condliffe, Janet Lord, Stephen Renshaw, Adriano Rossi, Sonja Vermeren, and Sarah Walmsley

REVIEWS

Free Access

Neutrophil subsets and their differential roles in viral respiratory diseases

  • Pages: 1159-1173
  • First Published: 18 January 2022
Neutrophil subsets and their differential roles in viral respiratory diseases
Graphical Abstract

Review on the role neutrophils play during viral respiratory diseases, evaluating their various pro- and anti- viral functions leading to disease resolution or pathology.

PRIMARY RESEARCH

Free Access

Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood

  • Pages: 1175-1184
  • First Published: 31 January 2022
Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood
Graphical Abstract

Dynamic sensitivity range of neutrophils to mechanical and chemical cues is determined.

CELL DEVELOPMENT, DIFFERENTIATION AND TRAFFICKING

Free Access

Periodontal ligament stem cells promote polarization of M2 macrophages

  • Pages: 1185-1197
  • First Published: 04 January 2022
Periodontal ligament stem cells promote polarization of M2 macrophages
Graphical Abstract

PDLSCs could promote M2 macrophage polarization and enhanced IL-4 and IL-13-induced M2 macrophage polarization via JNK pathways.

Free Access

Identification of liver-specific CD24+ invariant NK T cells with low granzyme B production and high proliferative capacity

  • Pages: 1199-1210
  • First Published: 03 November 2021
Identification of liver-specific CD24+ invariant NK T cells with low granzyme B production and high proliferative capacity
Graphical Abstract

Hepatic CD24+ iNKT cells show higher levels of proliferation, glucose metabolism and mTOR activity comparing to CD24- iNKT cells

INFLAMMATION, EXTRACELLULAR MEDIATORS AND EFFECTOR MOLECULES

Free Access

Heparanase is a regulator of natural killer cell activation and cytotoxicity

  • Pages: 1211-1224
  • First Published: 24 October 2021
Heparanase is a regulator of natural killer cell activation and cytotoxicity
Graphical Abstract

Heparanase contributes to natural killer cell cytotoxicity, activation, and cytokine production

HOST DEFENSE AND PATHOPHYSIOLOGY

Free Access

CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection

  • Pages: 1225-1234
  • First Published: 23 December 2021
CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection
Graphical Abstract

CEBPD can regulate PTX3 during A. fumiagatus infection.

Open Access

PAD4 controls chemoattractant production and neutrophil trafficking in malaria

  • Pages: 1235-1242
  • First Published: 10 November 2021
PAD4 controls chemoattractant production and neutrophil trafficking in malaria
Graphical Abstract

PAD4 promotes malaria immunopathology by regulating chemokine production in macrophages and enhancing recruitment of inflammatory cells.

TRANSLATIONAL AND CLINICAL IMMUNOLOGY

Open Access

CCR7+ dendritic cells sorted by binding of CCL19 show enhanced Ag-presenting capacity and antitumor potency

  • Pages: 1243-1251
  • First Published: 15 November 2021
CCR7+ dendritic cells sorted by binding of CCL19 show enhanced Ag-presenting capacity and antitumor potency
Graphical Abstract

Selection of CCR7+ DCs using chemically synthesized and tagged CCL19 selects a population of DC which improves anti-tumour immunity and efficacy in solid and metastatic tumour models.

REVIEWS

Free Access

Epigenetic regulation of T cells by Polycomb group proteins

  • Pages: 1253-1267
  • First Published: 25 April 2022
Epigenetic regulation of T cells by Polycomb group proteins
Graphical Abstract

Review of how PRC1 and 2 regulate T cell development, differentiation and function.

Free Access

Direct and indirect regulation of the tumor immune microenvironment by VEGF

  • Pages: 1269-1286
  • First Published: 25 April 2022
Direct and indirect regulation of the tumor immune microenvironment by VEGF
Graphical Abstract

Review on the function of vascular endothelial growth factor-A (VEGF) in regulating immune cells in the tumor microenvironment and theuse of anti-VEGF as cancer immunotherapy.

COVID-19 INITIATIVE

Free Access

Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathology

  • Pages: 1287-1295
  • First Published: 24 January 2022
Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathology
Graphical Abstract

A mucosal and lymphocyte migration marker (sMAdCAM) and IL-15, a cytokine regulating leukocyte activation and homeostasis, are associated with different states of immune pathology following COVID-19.