• Issue

    Journal of Leukocyte Biology: Volume 112, Issue 6

    1357-1716
    December 2022

ISSUE INFORMATION

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Issue Information

  • Pages: 1357-1363
  • First Published: 25 November 2022

LETTERS TO EDITOR

EDITORIAL COMMENTARY

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Aging and macrophages: Not standing the test of time?

  • Pages: 1369-1370
  • First Published: 29 June 2022
Aging and macrophages: Not standing the test of time?
Graphical Abstract

Advanced age leads to significant disruption in function of alveolar macrophages, which play a critical role in tissue homeostasis and anti-microbial defense.

SPOTLIGHT ON LEADING EDGE RESEARCH

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Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury

  • Pages: 1371-1386
  • First Published: 19 September 2022
Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury
Graphical Abstract

Healthy aging alters alveolar macrophage phenotype and responses to acute physiologic distress involving age-associated dysregulation of glucocorticoid signaling.

Cell Development, Differentiation and Trafficking

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Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology

  • Pages: 1387-1397
  • First Published: 02 August 2022
Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology
Graphical Abstract

Selenoprotein I increases during T cell activation and its expression is required for increased levels of the transcription factor, ROR gamma t, to drive Th17 differentiation.

Inflammation, Extracellular Mediators, and Effector Molecules

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The extracellular sialidase NEU3 primes neutrophils

  • Pages: 1399-1411
  • First Published: 28 July 2022
The extracellular sialidase NEU3 primes neutrophils
Graphical Abstract

The extracellular sialidase enzyme NEU3 is upregulated in fibrotic lesions, and here we show that extracellular recombinant human NEU3 partially desialylates and primes human neutrophils.

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Dectin-1 signaling in neutrophils up-regulates PD-L1 and triggers ROS-mediated suppression of CD4+ T cells

  • Pages: 1413-1425
  • First Published: 08 September 2022
Dectin-1 signaling in neutrophils up-regulates PD-L1 and triggers ROS-mediated suppression of CD4+ T cells
Graphical Abstract

Mechanisms by which Dectin-1 signaling in neutrophils promotes a cellular phenotype with T cell-suppressive properties.

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Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis

  • Pages: 1427-1443
  • First Published: 19 August 2022
Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis
Graphical Abstract

We identified the functions by which epigallocatechin-3-gallate effectively inhibits neutrophil elastase activity, reduces neutrophil extracellular trap formation, and attenuates systemic inflammatory response in acute pancreatitis.

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ILC3-like ILC2 subset increases in minimal persistent inflammation after acute type II inflammation of allergic rhinitis and inhibited by Biminkang: Plasticity of ILC2 in minimal persistent inflammation

  • Pages: 1445-1455
  • First Published: 26 September 2022
ILC3-like ILC2 subset increases in minimal persistent inflammation after acute type II inflammation of allergic rhinitis and inhibited by Biminkang: Plasticity of ILC2 in minimal persistent inflammation
Graphical Abstract

ILC3-like ILC characterized with IL-5+IL-17A+IL-23R+ was significantly increased of the airway in minimal persistent inflammation and it could be inhibited by the Chinese herbal medicine Biminkang.

Host Defense and Pathophysiology

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Campylobacter jejuni induces differentiation of human neutrophils to the CD16hi/CD62Llo subtype

  • Pages: 1457-1470
  • First Published: 22 July 2022
Campylobacter jejuni induces differentiation of human neutrophils to the CD16hi/CD62Llo subtype
Graphical Abstract

Campylobacter jejuni infection of neutrophils results in differentiation of a subtype which activates HIF-1 and NF-κB in colonocytes and decreases TCRζ in T cells.

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IL-22 and Lactobacillus delbrueckii mitigate alcohol-induced exacerbation of DSS-induced colitis

  • Pages: 1471-1484
  • First Published: 02 August 2022
IL-22 and Lactobacillus delbrueckii mitigate alcohol-induced exacerbation of DSS-induced colitis
Graphical Abstract

Lactobacillus delbrueckii produced protective effects following alcohol consumption and DSS colitis, and that Lactobacillus delbrueckii utilized the IL-22/STAT3 signaling pathway in mediating these effects.

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Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles

  • Pages: 1485-1495
  • First Published: 02 August 2022
Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles
Graphical Abstract

Differences in neutrophil functional capacity represent a fixed phenotype and are defined by distinct neutrophil gene expression profiles.

TRANSLATIONAL AND CLINICAL IMMUNOLOGY

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In vitro-induced Foxp3+CD8+ regulatory T cells suppress allergic IgE response in the gut

  • Pages: 1497-1507
  • First Published: 24 August 2022
In vitro-induced Foxp3+CD8+ regulatory T cells suppress allergic IgE response in the gut
Graphical Abstract

Foxp3+CD8+ Tregs suppress the allergic gut mucosal response and can be used as an adoptive cellular therapy to restore the oral tolerance to food antigens.

Meeting: Targeted Science Issue - 2021 SLB Virtual Annual Meeting

Guest Editors: Vidula Vachharajani, Laura Nagy

REVIEWS

Open Access

Sepsis, pyruvate, and mitochondria energy supply chain shortage

  • Pages: 1509-1514
  • First Published: 22 July 2022
Sepsis, pyruvate, and mitochondria energy supply chain shortage
Graphical Abstract

This review summarizes our research identifying mitochondrial pyruvate oxidative metabolism and its coupling to tricarboxylic (TCA) cycle resistance and disease tolerance energetics as pathway to sepsis survival.

Open Access

Metabolic impact of adipose tissue macrophages in the early postnatal life

  • Pages: 1515-1524
  • First Published: 28 July 2022
Metabolic impact of adipose tissue macrophages in the early postnatal life
Graphical Abstract

Macrophages in the adipose tissue affect adipocyte functioning in the early life, thereby may have a long-term impact on obesity status.

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Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis

  • Pages: 1525-1534
  • First Published: 04 October 2022
Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis
Graphical Abstract

Critically ill sepsis survivor patients show specific immunological endotypes, secondary to a persistent maladaptive reprioritization of myelopoiesis and pathological activation of myeloid cells.

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A novel strategy to dissect multifaceted macrophage function in human diseases

  • Pages: 1535-1542
  • First Published: 21 June 2022
A novel strategy to dissect multifaceted macrophage function in human diseases
Graphical Abstract

Review of the current models to understand dynamic actions of macrophages in various diseases and new strategies to characterize their molecular network using single-cell transcriptomics.

PRIMARY RESEARCH

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Contact-dependent, polarized acidification response during neutrophil–epithelial interactions

  • Pages: 1543-1553
  • First Published: 08 June 2022
Contact-dependent, polarized acidification response during neutrophil–epithelial interactions
Graphical Abstract

Inflammatory acidosis represents a polarized neutrophil-epithelial dependent response independent of myeloperoxidase and ion efflux.

Free Access

Divergent Golgi trafficking limits B cell-mediated IgG sialylation

  • Pages: 1555-1566
  • First Published: 21 June 2022
Divergent Golgi trafficking limits B cell-mediated IgG sialylation
Graphical Abstract

B cells secrete IgG antibodies through a pathways that promotes exposure to the enzyme Fut8 to promote N-glycan core fucosylation, yet limits exposure to ST6Gal1 to minimize alpha2,6 sialylation.

Meeting: Targeted Science Issue - 6th International Conference on Cancer Precision Medicine 2021

Guest Editors: Xiubao Ren, Jingting Jiang, Xiao Zheng, Quanli Gao, Jiuwei Cui, Yunbin Ye, and Feng Wei

PRIMARY RESEARCH

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Dysregulated Th1 cells in lung squamous cell carcinoma

  • Pages: 1567-1576
  • First Published: 10 June 2022
Dysregulated Th1 cells in lung squamous cell carcinoma
Graphical Abstract

Th1 cells' function is suppressed in LUSC. Through scRNA-seq, the decreased Th1 cells' function is associated with ER stress, which requires further study.

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Altered MUC1 epitope-specific CTLs: A potential target for immunotherapy of pancreatic cancer

  • Pages: 1577-1590
  • First Published: 12 October 2022
Altered MUC1 epitope-specific CTLs: A potential target for immunotherapy of pancreatic cancer
Graphical Abstract

Morphine with or without ART dysregulates functions of primary human macrophages, which may contribute to neuropathogenesis in opioid users living with HIV.

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Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer

  • Pages: 1591-1603
  • First Published: 02 May 2022
Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
Graphical Abstract

IL-33, TLS and PD-L1 are potentially valuable prognostic predictor for cervical cancer.

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The prognostic value of a 4-factor neoimmunologic score system in non-small cell lung cancer

  • Pages: 1605-1619
  • First Published: 08 September 2022
The prognostic value of a 4-factor neoimmunologic score system in non-small cell lung cancer
Graphical Abstract

A neoimmunologic score system was constructed based on 4 variables including CD3+, CD8+, FoxP3+, and PD-1+ immune cell densities in non-small cell lung cancer.

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Dynamic immune ecosystem of dengue infection revealed by single-cell sequencing

  • Pages: 1621-1631
  • First Published: 29 June 2022
Dynamic immune ecosystem of dengue infection revealed by single-cell sequencing
Graphical Abstract

Immune ecosystem of dengue infection analyzed to provide insights into the pathogenesis and treatment.

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Single-cell phenotypic profiling to identify a set of immune cell protein biomarkers for relapsed and refractory diffuse large B cell lymphoma: A single-center study

  • Pages: 1633-1648
  • First Published: 30 August 2022
Single-cell phenotypic profiling to identify a set of immune cell protein biomarkers for relapsed and refractory diffuse large B cell lymphoma: A single-center study
Graphical Abstract

Single-cell resolution provide more precise biomarkers than usual which may substantially overcome intertumoral and intratumoral heterogeneity among Relapsed and Refractory DLBCL patients

Meeting: Targeted Science Issue - The 9th International Gamma Delta T Cell Conference for 2021

Guest Editors: Zhinan Yin, Wenwei Tu, Jian Huang, Jianlei Hao, and Zheng Xiang

REVIEWS

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The role of γδ T17 cells in cardiovascular disease

  • Pages: 1649-1661
  • First Published: 08 September 2022
The role of γδ T17 cells in cardiovascular disease
Graphical Abstract

This review provides a more comprehensive understanding of the biology of γδ cells and their role in CVD.

Free Access

γδ T cells: The potential role in liver disease and implications for cancer immunotherapy

  • Pages: 1663-1668
  • First Published: 13 September 2022
γδ T cells: The potential role in liver disease and implications for cancer immunotherapy

Graphical Abstract: Review on the molecular mechanisms of γδ T cells in liver disease and its implications for clinical immunotherapy.

Open Access

γδ T cell exhaustion: Opportunities for intervention

  • Pages: 1669-1676
  • First Published: 24 August 2022
γδ T cell exhaustion: Opportunities for intervention
Graphical Abstract

Review of the characteristics, heterogeneity and mechanisms of γδ T cell exhaustion provides insights into the combined strategies to enhance γδ T cell-based anti-tumor immunotherapy.

PRIMARY RESEARCH

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IL-1β/NF-κB signaling inhibits IGF-1 production via let-7f-5p in dendritic epidermal T cells

  • Pages: 1677-1690
  • First Published: 19 September 2022
IL-1β/NF-κB signaling inhibits IGF-1 production via let-7f-5p in dendritic epidermal T cells
Graphical Abstract

Molecular mechanisms identified by which IL-1β/NF-κB down-regulates IGF-1 expression by let-7f-5p in dendritic epidermal T cells.

Free Access

TIGIT-expressing zoledronate-specific γδ T cells display enhanced antitumor activity

  • Pages: 1691-1700
  • First Published: 10 November 2022
TIGIT-expressing zoledronate-specific γδ T cells display enhanced antitumor activity
Graphical Abstract

TIGIT expressing, ZOL-specific γδ T cells are not exhausted, but more functional in antitumor immune response.

Free Access

Reviving human γδT cells from apoptosis induced by IL-12/18 via p-JNK inhibition

  • Pages: 1701-1716
  • First Published: 30 June 2022
Reviving human γδT cells from apoptosis induced by IL-12/18 via p-JNK inhibition
Graphical Abstract

p-JNK inhibitor treatment effectively revived human γδT cells from the apoptosis induced by IL-12/18 and maintained their enhanced IFN-γ production and cytotoxicity against tumor cells.